DAMP VanR - Pilot F003
GROQ-seq function measurements for VanR transcription factor pilot
About This Dataset
The project aims to generate sequence → function data for allosteric transcription factors, supporting applications in synthetic biology, biosensors, and therapeutics.
This dataset contains GROQ-seq measurements of VanR variant libraries (SSVL, epPCR, and SS) assayed at the DAMP Laboratory (Boston University), with a companion LMSF (NIST) dataset for cross-site reproducibility.
Dataset Information
- Owning Organization
- Wyss Institute
- Gene
- VanR
- Released
- Mar 16, 2026
Experiment Details
- total Records
- 13,816
- host Organism
- Escherichia coli
- antibiotic
- Trimethoprim
- experiment Date
- 8/16/2025
- collection Site
- DAMP
Downloads
TF_DAMP_VanR_output_v1.zip
Final output file containing function values
1.4 MB
TF_DAMP_Supplemental_v1.zip
Supplemental data including QC analysis notebooks
586.5 MB
README.md
Dataset README with project background and methodology overview
14.3 KB
Uncertainty Estimation Methodology.md
Uncertainty estimation methodology used for function measurements
10.6 KB
Figures
Reproducibility plot showing correlation between LMSF (NIST) and DAMP collection sites for VanR (plotting the log_g_100_Van values)