The 2025 Protein Engineering Tournament starts in:
Registration Open
Predictive (Zero Shot)
Predictive (Supervised)
Generative (Round 1)
Synthesizing & Testing
Generative (Round 2)
Final Results
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The Protein Engineering Tournament
A global benchmarking initiative hosted by The Align Foundation. This community-driven challenge empowers researchers to evaluate and improve predictive and generative models in protein engineering through collaboration, transparency, and rapid progress in AI-powered protein design.
Why Participate?
$30,000 in cash prizes
DNA synthesis and experimental testing of your designs
Leader-board recognition alongside leading researchers
Access to high quality protein engineering datasets
Co-authorship in a special issue publication
Invitation to present at key conference
Impact: Help solve plastic waste crisis
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HOW IT WORKS
The 2025 tournament includes two consecutive phases:
Select teams from the Predictive Phase will advance to the Generative Phase.
Click on either phase below to see the detailed steps
PREDICTIVE PHASE
DEC. 1, 2025 – FEB. 20, 2026
Predict properties of PETase variants (activity under two conditions and expression).
Two Tracks
GENERATIVE PHASE
MAR. 9 – AUG. 14, 2026
Design novel PETase sequences with enhanced activity under multiple conditions while maintaining expression.
- •Designs are experimentally synthesized and tested.
- •Two iterative design rounds with feedback between the rounds
If you are a team lead and have submitted the required access form, you can sign in below:
Registration for the 2025 tournament has closed. Stay tuned for upcoming tournaments!
Anonymous Team Names
Registered Team Leads: Once you sign in, you will be assigned an anonymous team name for tournament leaderboards.
You can view your assigned team name by visiting your tournaments tab on your profile page or click here.
