TEV Protease - Pilot ML Libraries

The project aims to collect data on thousands of protease sequence variants, with applications in understanding protease specificity and developing therapeutic interventions.

This dataset contains GROQ-seq measurements of a TEV protease library designed by seven generative protein-design models (PSSM, EVCouplings, EVE, ESM2, Tranception, ESM-IF1, ProteinMPNN) alongside an epPCR baseline, benchmarking generative methods against experimental function. Assayed via split-DHFR at the Living Measurement Systems Foundry (LMSF) at NIST.