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TEV Protease - Homolog Library
GROQ-seq function measurements for TEV protease homolog libraries
Version:
About This Dataset
The project aims to collect data on thousands of protease sequence variants, with applications in understanding protease specificity and developing therapeutic interventions.
This dataset contains GROQ-seq measurements of a sequence-diverse TEV protease library: 4,022 natural homologs (from JackHMMER searches of UniRef100, BFD, and MGnify) plus 422 AI-generated variants from the SCISOR discrete-diffusion model, spanning broad evolutionary distance from TEV protease S219V. Assayed via split-DHFR at the Living Measurement Systems Foundry (LMSF) at NIST.
Dataset Information
- Owning Organization
- The Align Foundation
- Gene
- TEV
- Released
- Mar 30, 2026
Experiment Details
- total Records
- 11,731
- host Organism
- Escherichia coli
- antibiotic
- Trimethoprim
- experiment Date
- 12/15/2025
- collection Site
- LMSF